The diverse genetic landscape of neurodevelopmental disorders.
نویسندگان
چکیده
Advances in genetic tools and sequencing technology in the past few years have vastly expanded our understanding of the genetics of neurodevelopmental disorders. Recent high-throughput sequencing analyses of structural brain malformations, cognitive and neuropsychiatric disorders, and localized cortical dysplasias have uncovered a diverse genetic landscape beyond classic Mendelian patterns of inheritance. The underlying genetic causes of neurodevelopmental disorders implicate numerous cell biological pathways critical for normal brain development.
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عنوان ژورنال:
- Annual review of genomics and human genetics
دوره 15 شماره
صفحات -
تاریخ انتشار 2014